Synthetic proteins with over one hundred residues long can now be assembled by employing techniques such as native chemical ligation. This critical advance allows for the efficient incorporation of post-translational modifications, non-natural residues and site-specific isotopic labelling in proteins, which is often prohibitive when using recombinant DNA techniques. Modpep has the ability to design and synthesise these large biological constructs in a cost-effective manner to a high degree of purity (PDB image ID: 1IAZ).
